Last edited by Nikazahn
Thursday, April 30, 2020 | History

1 edition of Fertility and outcome of pregnancy in women exposed in utero to diethylstilbestrol found in the catalog.

Fertility and outcome of pregnancy in women exposed in utero to diethylstilbestrol

Fertility and outcome of pregnancy in women exposed in utero to diethylstilbestrol

  • 148 Want to read
  • 31 Currently reading

Published by Dept. of Health, Education, and Welfare, [Public Health Service], National Institutes of Health in [Bethesda, Md.] .
Written in English

    Subjects:
  • Fertility,
  • Pregnancy -- Complications,
  • Diethylstilbestrol -- Side effects

  • Edition Notes

    StatementAnn B. Barnes ... [et al.]
    ContributionsBarnes, Ann, National Institutes of Health (U.S.)
    The Physical Object
    Paginationp. 609-613 ;
    Number of Pages613
    ID Numbers
    Open LibraryOL14904012M

    A t-shaped uterus is a type of uterine malformation wherein the uterus is shaped resembling the letter T. This is typically observed in DES-exposed women. It is recognised in the ESHRE/ESGE classification, and is associated with failed implantation, increased risk of ectopic pregnancy, miscarriage and preterm delivery. There is a surgical procedure to correct the malformation. Diethylstilbestrol (DES) is a powerful synthetic estrogen that acts as a transplacental carcinogen in humans. Beginning around and continuing through the s, DES was given to as many as 2 million pregnant women in the United States under the mistaken belief that it would reduce risk of miscarriage and complications of pregnancy. 1 The now well-established adverse effects of in utero. Forty-six infertile women with a history of diethylstilbestrol (DES) exposure in utero underwent stimulation attempts for in vitro fertilization (IVF). The mean (±SE) number of preovulatory oocytes harvested at retrieval and transferred was ± (/) and ± (/). When compared with patients with tubal factor infertility and ≤4 pre-embryos transferred, the clinical Cited by:


Share this book
You might also like
Advances in special education.

Advances in special education.

Delius.

Delius.

Smallpox in its relation to vaccination and other means designed for its prevention with a critical examination of a thousand recent cases

Smallpox in its relation to vaccination and other means designed for its prevention with a critical examination of a thousand recent cases

life of Napoleon I

life of Napoleon I

Tintin and the lake of sharks

Tintin and the lake of sharks

Womens liberation and the new politics

Womens liberation and the new politics

Life in the laboratory

Life in the laboratory

David Garrick

David Garrick

Macroeconomics

Macroeconomics

Windows Me Millennium

Windows Me Millennium

Dealing with Damascus

Dealing with Damascus

Pro #1

Pro #1

Examination parity and year 2000 readiness for financial institutions Act

Examination parity and year 2000 readiness for financial institutions Act

Time for my soul

Time for my soul

Fertility and outcome of pregnancy in women exposed in utero to diethylstilbestrol Download PDF EPUB FB2

Original Article from The New England Journal of Medicine — Fertility and Outcome of Pregnancy in Women Exposed in Utero to Diethylstilbestrol logo logoCited by:   Fertility and outcome of pregnancy were examined in women participating in the National Cooperative Diethylstilbestrol Adenosis (DESAD) Project.

We compared subjects who had prenatal exposure to DES with control subjects. Fertility, measured in terms of pregnancies achieved, did not differ between the women exposed to DES and the by:   Fertility and outcome of pregnancy in women exposed in utero to diethylstilbestrol.

N Engl J Med. Mar 13; (11)– Henderson BE, Benton B, Cosgrove M, Baptista J, Aldrich J, Townsend D, Hart W, Mack TM.

Urogenital tract abnormalities in sons of women treated with diethylstilbestrol. Pediatrics. Oct; 58 (4)–Cited by: 2. Fertility and outcome of pregnancy in women exposed in utero to diethylstilbestrol, The New England journal of medicine, NCBI PubMed PMID:Mar Fertility and outcome of pregnancy were examined in women participating in the National Cooperative Diethylstilbestrol Adenosis (DESAD) Project.

PIP Current knowledge regarding the pregnancy outcome for women exposed to DES (diethylstilbestrol) in utero is presented using information from a. Fertility and outcome of pregnancy in women exposed in utero to diethylstilbestrol.

N Engl J Med. Mar 13; (11)– Bibbo M, Haenszel WM, Wied GL, Hubby M, Herbst AL. A twenty-five-year follow-up study of women exposed to diethylstilbestrol during pregnancy.

N Engl J Med. Apr 6; (14)–Author: Michael Malus, Alex Ferenczy. The presence of anomalies in vagina, cervix, and uterine body of women exposed to diethylstilbestrol in utero has provoked interest and concern regarding the reproductive potential of these women. To expand and to evaluate better better the current knowledge in this matter, the outcomes of the pregnancies of exposed women registered in the Stilbestrol Clinic at the Stanford.

In utero exposure of women to DES is associated with a high lifetime risk of a broad spectrum of adverse health outcomes. Abstract. Adverse health outcomes in women exposed in utero to diethylstilbestrol, The New England journal of medicine, NCBI PubMed PMID:Oct. Full text: NEJM, DOI: /NEJMoa, October 6, BACKGROUND.

Purpose: The outcome of in vitro fertilization (IVF) in a group of infertile women with a history of in utero exposure to diethylstilbestrol (DES) was analyzed. Records from an academic IVF program were retrospectively reviewed.

Methods: Seventeen infertile women with a self-reported history of exposure to DES in utero, Cited by: 9. Fertility and outcome of pregnancy in women exposed in utero to diethylstilbestrol.

Impaired reproductive performance in DES-exposed women. Association of diethylstilbestrol exposure in utero with cryptorchidism, testicular hypoplasia and semen abnormalities. Barnes AB, Colton T, Gundersen J, et al. Fertility and outcome of pregnancy in women exposed in utero to diethylstilbestrol.

N Engl J Med ; Full Text; Web of Science; Medline Cited by: Fertility and outcome of pregnancy in women exposed in utero to diethylstilbestrol.

[Bethesda, Md.]: Dept. of Health, Education, and Welfare [Public Health Service], National Institutes of Health, (OCoLC) Material Type: Government publication, National government publication: Document Type: Book: All Authors / Contributors.

Assisted reproductive technology Are implantation and pregnancy outcome impaired in diethylstilbestrol-exposed women after in vitro fertilization and embryo transfer?* * Presented in part at the 38th Annual Meeting of The American College of Obstetricians and Gynecologists, San Francisco, California, May 7 to 10, Cited by: The chapter gives an overview of medical drugs impairing fertility in men and women.

Drugs may impair male fertility by interfering with spermatogenesis, sperm motility, or by interfering with the fertilising capacity of spermatozoa. Female fertility may be compromised by impairing oogenesis, ovulation, or through the suppression of ovarian Cited by: 4.

Diethylstilbestrol (DES) is a synthetic form of the female hormone was prescribed to pregnant women between and to prevent miscarriage, premature labor, and related complications of pregnancy ().The use of DES declined after studies in the s showed that it was not effective in preventing these problems.

Fertility and outcome of pregnancy were examined in women participating in the National Cooperative Diethylstilbestrol Adenosis (DESAD) Project. We compared subjects who had prenatal exposure.

R.H. Kaufman, E. Adam, G.L. Binder, E. Gerthoffer, Upper genital tract changes and pregnancy outcome in offspring exposed in utero to diethylstilbestrol Am J Obstet Gynecol () G. Schmidt, W.C. Fowler, Cervical stenosis following minor gynecologic procedures on DES-exposed women Obstet Gynecol () Cited by: These data suggest that in utero exposure to DES results in permanent impairment of female mouse reproductive capacity.

Recent reports of altered pregnancy outcomes in young women who were exposed in utero to DES demonstrate the clinical importance of the findings obtained in mice. REFERENCES by: Scientific Articles Experience with diethylstilbestrol-exposed infertile women in a program of in vitro fertilization Suheil J.

Muasher, M.D. * Jairo E. Garcia, M.D. Howard W. Jones, Jr. M.D. Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, Virginia Department of Obstetrics and Gynecology, Eastern Virginia Medical School Norfolk Virginia * Reprint requests Cited by: In addition, researchers found that the timing of DES exposure in the womb (the trimester (s) during which exposure to DES took place) had some effect on infertility rates.

Specifically, 24% of DES Daughters had never become pregnant compared with 18% of unexposed women. Most DES Daughters who never became pregnant had been exposed to DES. Diethylstilbestrol (DES) is a polycyclic nonsteroidal estrogen that readily crosses the placenta and has been shown, in animal studies, to concentrate in the urogenital tract of the developing fetus (1, 2, 3).Worldwide, between 1 and 4 million men and women were exposed prenatally to DES from about through the s ().Numerous studies have shown that women who were exposed to DES Cited by: Outcome of pregnancy in patients exposed in utero to diethylstilbestrol.

Survey by the National College of French Gynecologists and Obstetricians. Pregnancy after gamete intrafallopian transfer in a woman with primary infertility and in utero exposure to diethylstilbestrol.

Barnes, A. B., Colton, T., Gunderson et al. Fertility and outcome of pregnancy in women exposed in utero to diethylstilbestrol. Engl. Med.,Cited by: 1. Barnes AB, Colton T, Gundersen J, et al. Fertility and outcome of pregnancy in women exposed in utero to diethylstilbestrol. N Engl J Med ; - Full TextCited by: 1.

J Reprod Med. Dec;28(12) Infertility in women exposed to diethylstilbestrol in utero. Haney AF, Hammond MG. To evaluate the reproductive consequences of prenatal diethylstilbestrol (DES) exposure, 33 infertile couples were studied in whom the female had been exposed to DES in by: Conservative management and pregnancy outcome in diethylstilbestrol-exposed women with and without gross genital tract abnormalities.

Am J Obstet Gynecol ; Wise LA, Palmer JR, Hatch EE, et al. Secondary sex ratio among women exposed to diethylstilbestrol in utero. Fertility and outcome of pregnancy in women exposed in utero to diethylstilbestrol.

Impaired reproductive performance in DES-exposed women. Association of diethylstilbestrol exposure in utero with cryptorchidism, testicular hypoplasia and semen abnormalities. DES Effect on Males.

Adverse outcomes of pregnancy in women exposed to diethylstilbestrol in utero. J Reprod Med ;33(1) Mangan CE, Borow L, Burtnett-Rubin MM, Egan V, Giuntoli RL, Mikuta JJ. Pregnancy outcome in 98 women exposed to diethylstilbestrol in utero, their mothers, and unexposed siblings. Obstet Gynecol ; Muasher SJ, Garcia JE, Jones HW.

Barnes AB, Colton T, Gundersen J, et al: Fertility and the outcome of pregnancy in women exposed in utero to diethylstilbestrol. N Engl J Med –, PubMed CrossRef Google Scholar Author: David F. Archer.

Genital tract abnormalities and adverse pregnancy outcome are well known in women exposed in utero to diethylstilboestrol (DES). Data about adverse reproductive performance in women exposed to DES have been published, including controversial reports of menstrual dysfunction, poor responses after ovarian stimulation, oocyte maturation and fertilization by: Adverse Outcomes in Women Exposed to Diethylstilbestrol n engl j med ;14 october 6, S oon after the first synthetic estro-gen, diethylstilbestrol (DES), was developed in ,1 it was used clinically to prevent complications of pregnancy.2 In the early s, four clinical trials revealed no evidence of efficacy.

Women who were exposed to diethylstilbestrol in utero commonly have malformations of the uterus, cervix, and fallopian tubes, all of which are associated with a higher prevalence of unfavorable pregnancy outcomes (1 –9).Spontaneous abortion, ectopic pregnancy, and preterm delivery are more common among diethylstilbestrol-exposed women ().Whether diethylstilbestrol-exposed women Cited by: Adverse outcomes of pregnancy in women exposed to diethylstilbestrol in utero.

J Reprod Med ;33(1) Mangan CE, Borow L, Burtnett-Rubin MM, Egan V, Giuntoli RL, Mikuta JJ. Pregnancy outcome in 98 women exposed to diethylstilbestrol in utero, their mothers, and unexposed siblings.

Obstet Gynecol ; The authors conclude that DES exposure in utero in this study group was not associated with increased difficulty in conceiving or early pregnancy complications.

However, among pregnancies that progressed beyond 20 weeks' gestation, the incidence of premature delivery was significantly increased and associated with an increased perinatal mortality.

Women who were exposed to diethylstilbestrol in utero may have structural reproductive tract anomalies, an increased infertility rate, and poor pregnancy outcomes.

However, the majority of. Diethylstilbestrol (DES), also known as stilbestrol or stilboestrol, is a nonsteroidal estrogen medication, which is rarely used. In the past, it was widely used for a variety of indications, including pregnancy support for women with a history of recurrent miscarriage, hormone therapy for menopausal symptoms and estrogen deficiency in women, treatment of prostate cancer in men and breast Metabolism: Hydroxylation, oxidation, glucuronidation.

Adverse Health Outcomes in Women Exposed In-Utero to Diethylstilbestrol. Adenocarcinoma of the Vagina in Women Aged 14 to 22 at the MGH, Twelve Adverse Health Outcomes Associated with In-Utero Exposure to DES in the Combined Cohort Study of DES Exposure Ectopic pregnancy ( to ) Loss of second-trimester pregnancy 3.

Women who were exposed to diethylstilbestrol in utero may have structural reproductive tract anomalies, an increased infertility rate, and poor pregnancy outcomes. Barnes AB, Colton T, Gundersen J, Noller KL, Tilley BC, Strama T, et al.

Fertility and outcome of pregnancy in women exposed in utero to diethylstilbestrol. N Eng J Med ;(11) Ben-Baruch G, Menczer J, Mashiach S, Serr DM. Uterine anomalies in diethylstilbestrol-exposed women with fertility disorders.

These anomalies contribute to an increased risk of infertility and adverse pregnancy outcomes in prenatally DES-exposed daughters.

6th edition () lists diethylstilbestrol (pp. –76) as a nonsteroidal estrogen with carcinogenic properties An increased risk of ovarian cancer in the daughters of women exposed in utero was. Beforeseveral million women were exposed in utero to diethylstilbestrol (DES) given to their mothers to prevent pregnancy complications.Cancer Risk in Women Exposed to Diethylstibestrol in Utero (Hatch et al., ) In this study, the researchers wanted to learn whether women exposed to DES before birth (in the womb), known as DES Daughters, were more likely to develop cancer than unexposed women.title = "Adverse health outcomes in women exposed in utero to diethylstilbestrol", abstract = "BACKGROUND: Beforeseveral million women were exposed in utero to diethylstilbestrol (DES) given to their mothers to prevent pregnancy by: